Deductive Biocomputing

Deductive Biocomputing

BACKGROUND As biologists increasingly rely upon computational tools, it is imperative that they be able to appropriately apply these tools and clearly understand the methods the tools employ. Such tools must have access to all the relevant data and knowledge and, in some sense, "understand" biology so that they can serve biologists' goals appropriately and "explain" in biological terms how resu...

Whole-cell biocomputing.

The ability to manipulate systems on the molecular scale naturally leads to speculation about the rational design of molecular-scale machines. Cells might be the ultimate molecular-scale machines and our ability to engineer them is relatively advanced when compared with our ability to control the synthesis and direct the assembly of man-made materials. Indeed, engineered whole cells deployed in...

Geneways for Biocomputing

Structural Biology and Biocomputing Programme

ɗ Reconstruct the structural details of protein complexes that are active in cell adhesion and metabolism. ɗ Predict the consequences of cancer related alterations ; we are focusing on alterations with a compensatory nature ( co-evolutionary related mutations ) as well as those affecting alternative splicing patterns. ɗ Contribute to the analysis of cancer epigenomic and genomic information wit...

Biocomputing based on particle disassembly.

Nanoparticles with biocomputing capabilities could potentially be used to create sophisticated robotic devices with a variety of biomedical applications, including intelligent sensors and theranostic agents. DNA/RNA-based computing techniques have already been developed that can offer a complete set of Boolean logic functions and have been used, for example, to analyse cells and deliver molecul...